J. L. Mueller

Development of a 3D in vitro human-sized model of cervical dysplasia to evaluate the delivery of ethyl cellulose-ethanol injection for the treatment of cervical dysplasia ablation

This study develops a 3D in vitro model of cervical dysplasia to evaluate the efficacy of EC-ethanol injection for treating cervical dysplasia ablation.

An integrated signaling threshold initiates IgG response towards virus-like immunogens

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state

This study shows neuroblastoma cells can switch between a neuronal gene expression state and a de-differentiated state, with CD49b marking proliferative immature cells and CD49b-negative cells capable of generating tumors.

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

This study shows that NR4A family members are essential for multiple T cell tolerance mechanisms, preventing autoimmunity even when Tregs are intact.

Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

This study shows that NUR77/Nr4a1 negatively regulates B cell clonal dominance in early T-dependent immune responses to maintain diversity in the germinal center niche.

Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model

This study evaluates a polymer-assisted ethanol ablation method in a murine breast cancer model, finding it safer and more effective than conventional ethanol ablation.

A 3D Reconstruction Algorithm for Real-time Simultaneous Multi-Source EIT Imaging for Lung Function Monitoring

This paper presents a 3D EIT algorithm for real-time lung function monitoring using simulated data, phantoms, and human subjects.

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.