An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics
Y. Yang, Z. t. Song, T. Tian, Z. Zhao, J. Chen, J. p. Hu, X. Jiang, G. l. Yang, Q. Xue, X. l. Zhao, W. x. Sha, Y. Yang, J. P. Li
This paper demonstrates a method to efficiently conjugate biomacromolecules to antibodies using modified Fc glycan and an engineered enzyme, enabling rapid and homogeneous antibody conjugates with therapeutic applications.
bioRxiv · Sep 4, 2022 · PreprintBiochemistry