J. Chen

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

Tim-3 promotes viral infection by suppressing USP25-TRAF3-IRF7 signaling pathway

This study shows Tim-3 suppresses antiviral immunity by inhibiting the USP25-TRAF3-IRF7 signaling pathway in myeloid cells during VSV encephalitis.

Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

DePARylation is critical for S phase progression and cell survival

This study shows that dePARylation by PARG is essential for S phase progression and cell survival, with PARG inhibition causing cytotoxicity through pADPr accumulation.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

Simultaneous generation of osteoblasts and adipocytes by a bivalent differentiation medium from bone marrow stromal/stem cells (BMSCs)

This paper introduces a bivalent differentiation medium that enables BMSCs to simultaneously generate osteoblasts and adipocytes, with a method to assess lineage commitment using staining techniques.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

snoRNA-guided tRNA 2'-O-methylation controls codon-biased gene expression and cellular states

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Three-dimensional structured illumination microscopy with enhanced axial resolution

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

Experimental study of modified human tendon stem cells to promote graft ligamentation and tendon-bone healing after anterior cruciate ligament reconstruction

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

The paper introduces an automated feeding system for African killifish to study dietary restriction effects on lifespan and cognitive behavior, showing sex-specific transcriptome changes and extending male lifespan.

Membrane-remodeling protein ESCRT-III homologs incarnate the evolution and morphogenesis of multicellular magnetotactic bacteria

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics

This paper demonstrates a method to efficiently conjugate biomacromolecules to antibodies using modified Fc glycan and an engineered enzyme, enabling rapid and homogeneous antibody conjugates with therapeutic applications.

Canonical and Replicable Multi-Scale Intrinsic Connectivity Networks in 100k+ Resting-State fMRI Datasets

The paper develops a reliable network template and methods to estimate individualized functional networks from resting-state fMRI data across 100k+ individuals, showing how data length and spatial resolution affect network estimation.

Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport

The paper identifies a P4-ATPase gene in a fungus that mediates detoxification of immunosuppressants via vesicle transport, with cross-species resistance applications in plants and human health.

Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D

This study identifies the N-terminal domain (NTD) of p53 as the major binding site for Cyclophilin D, revealing dynamic electrostatic interactions and a minimal binding region for mPTP regulation.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Incorporating the image formation process into deep learning improves network performance in deconvolution applications

This paper introduces RLN, a deep learning method for 3D fluorescence microscopy deconvolution that improves speed, performance, and generalizability compared to existing methods.

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

Chromatin reprogramming and transcriptional regulation orchestrate embryogenesis in hexaploid wheat

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.