Author

W. Yashar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

B. J. Druker· 2 shared B. M. Smith· 2 shared D. J. Coleman· 2 shared J. E. Maxson· 2 shared J. Estabrook· 2 shared T. P. Braun· 2 shared A. Taherinasab· 1 shared C. Coblentz· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

B. J. Druker

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2 papers

Recent·Most cited

PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

B. M. Smith, J. VanCampen, G. L. Kong, W. Yashar, Y. H. Tsang, W. Horton, D. J. Coleman, J. Estabrook, T. A. Lusardi, G. B. Mills, B. J. Druker, J. E. Maxson, T. P. Braun

This paper shows that combining KIT and LSD1 inhibitors synergistically kills KIT-mutant AML cells by reducing MYC expression and inactivating PI3K/AKT signaling, supporting a clinical trial.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.

T. P. Braun, J. Estabrook, L. Darmusey, D. J. Coleman, Z. Schonrock, B. M. Smith, T. Enright, A. Taherinasab, C. Coblentz, W. Yashar, R. Callahan, H. Mohammed, B. J. Druker, T. Lusardi, J. E. Maxson

This study identifies ASXL1's role in neutrophil differentiation by modulating MYC and RNA Polymerase II, showing its impact on granulocyte maturation and myeloid malignancies.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology