Author

D. J. Coleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. J. Druker· 3 shared B. M. Smith· 3 shared J. E. Maxson· 3 shared J. Estabrook· 3 shared T. P. Braun· 3 shared J. VanCampen· 2 shared W. Yashar· 2 shared A. Adamo· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

B. J. Druker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

S. G. Kellaway, S. Potluri, P. Keane, H. Blair, P. S. Chin, A. Ptasinska, A. Worker, L. Ames, A. Adamo, D. J. Coleman, N. Khan, S. Assi, A. Krippner-Heidenreich, M. Raghavan, P. N. Cockerill, , C. Bonifer

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

bioRxiv · Mar 10, 2023Cancer Biology

Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

W. M. Yashar, B. M. Smith, D. J. Coleman, J. VanCampen, G. Kong, J. Macaraeg, J. Estabrook, E. Demir, N. Long, D. Bottomly, S. K. McWeeney, J. W. Tyner, B. J. Druker, J. E. Maxson, T. P. Braun

This study shows that combining FLT3 and LSD1 inhibitors synergistically kills FLT3-mutant AML cells by disrupting the MYC super-enhancer complex.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

B. M. Smith, J. VanCampen, G. L. Kong, W. Yashar, Y. H. Tsang, W. Horton, D. J. Coleman, J. Estabrook, T. A. Lusardi, G. B. Mills, B. J. Druker, J. E. Maxson, T. P. Braun

This paper shows that combining KIT and LSD1 inhibitors synergistically kills KIT-mutant AML cells by reducing MYC expression and inactivating PI3K/AKT signaling, supporting a clinical trial.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.

T. P. Braun, J. Estabrook, L. Darmusey, D. J. Coleman, Z. Schonrock, B. M. Smith, T. Enright, A. Taherinasab, C. Coblentz, W. Yashar, R. Callahan, H. Mohammed, B. J. Druker, T. Lusardi, J. E. Maxson

This study identifies ASXL1's role in neutrophil differentiation by modulating MYC and RNA Polymerase II, showing its impact on granulocyte maturation and myeloid malignancies.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology