Author

W. Horton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

C. Oon· 2 shared M. H. Sherman· 2 shared S. Bhattacharyya· 2 shared A. Kothari· 1 shared A. Sattler· 1 shared A. Sebastian· 1 shared B. J. Druker· 1 shared B. M. Smith· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

C. Oon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts

E. J. Helms, M. W. Berry, R. C. Chaw, C. C. DuFort, D. Sun, M. K. Onate, C. Oon, S. Bhattacharyya, H. Sanford-Crane, W. Horton, J. M. Finan, A. Sattler, R. Makar, D. W. Dawson, Z. Xia, , M. H. Sherman

The paper identifies a minor subset of pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) that have non-redundant functions in shaping the tumor microenvironment.

Cancer Discovery · Sep 21, 2021Peer-reviewedCancer Biology

PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

B. M. Smith, J. VanCampen, G. L. Kong, W. Yashar, Y. H. Tsang, W. Horton, D. J. Coleman, J. Estabrook, T. A. Lusardi, G. B. Mills, B. J. Druker, J. E. Maxson, T. P. Braun

This paper shows that combining KIT and LSD1 inhibitors synergistically kills KIT-mutant AML cells by reducing MYC expression and inactivating PI3K/AKT signaling, supporting a clinical trial.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

Effect of Adolescent Stress on Adult Morphine-Induced Behavioral Sensitization is Dependent Upon Genetic Background

H. Kamens, C. Miller, J. Caulfield, D. Zeid, W. Horton, C. Silva, A. Sebastian, I. Albert, T. Gould, D. Fishbein, P. S. Grigson, S. Cavigelli

This study investigates how adolescent stress affects adult morphine behavior, finding genetic differences in how C57BL/6J and BALB/cJ mice respond to stress and morphine.

bioRxiv · Jan 20, 2021 · PreprintAnimal Behavior & Cognition

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

S. Bhattacharyya, C. Oon, A. Kothari, W. Horton, J. Link, R. C. Sears, M. H. Sherman

This study identifies FGF1 from cancer-associated fibroblasts as a paracrine regulator of MYC in pancreatic cancer, showing its role in MYC stability and tumor formation.

bioRxiv · Jul 22, 2019Cancer Biology