Magnesium depletion unleashes two unusual modes of colistin resistancewith different fitness costs
Yu-Ying Phoebe Hsieh, Ian P. O’Keefe, Zeqi Wang, Wanting Sun, Hyojik Yang, Linda My Vu, Nicole E. Smalley, Robert K. Ernst, Ajai A. Dandekar, Harmit Singh Malik
This study identifies two distinct mechanisms of colistin resistance in P. aeruginosa driven by magnesium depletion, each with different fitness costs.
PLoS Biology · Mar 3, 2026Peer-reviewedMicrobiology