Ajai A. Dandekar

Analysis of the DNA-binding domain of the Pseudomonas aeruginosa quorum sensing transcription factor LasR

The paper investigates mutations in the DNA-binding domain of LasR, a LuxR homolog in Pseudomonas aeruginosa, finding some variants enhance regulation of RhlR-target genes but confer fitness defects.

A three-component logic gate governs quorum sensing-regulated killing of Stenotrophomonas maltophilia by Pseudomonas aeruginosa

This study identifies a three-component logic gate involving HQNO, PqsE, and PQS biosynthesis that governs Pseudomonas aeruginosa-mediated killing of Stenotrophomonas maltophilia.

Magnesium depletion unleashes two unusual modes of colistin resistancewith different fitness costs

This study identifies two distinct mechanisms of colistin resistance in P. aeruginosa driven by magnesium depletion, each with different fitness costs.

Quorum sensing antiactivators constrain Pseudomonas aeruginosa RhlR activity

This study investigates how QteE and QslA antiactivators modulate RhlR activity in Pseudomonas aeruginosa, revealing their distinct and overlapping roles in quorum sensing regulation.

Modulation of the Pseudomonas aeruginosa quorum sensing cascade by MexT-regulated factors

This paper identifies MexT-regulated factors that modulate quorum sensing hierarchy in Pseudomonas aeruginosa, revealing alternative QS architectures in clinical isolates.

Inactivation of MexT in Pseudomonas aeruginosa destabilizes cooperation and favors the emergence of a unique quorum sensing variant

The paper shows that inactivating MexT in Pseudomonas aeruginosa destabilizes cooperation and promotes the emergence of a specific LasR variant.

Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa

This study investigates how the nitrogen phosphotransferase system (PTSNtr) in Pseudomonas aeruginosa regulates quorum sensing, showing that PtsO and PtsN have distinct roles and regulons in controlling virulence gene expression.