A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek Simay Gokulu, Sophia Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Peter V. Hornbeck, Jing Li, Anum Azam Glasgow, Neil Vasan
This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.
Nature Communications · Mar 3, 2026Peer-reviewedCancer Biology