Author

Peter V. Hornbeck

Cell Signaling Technology (United States)ORCID 0000-0002-1126-5149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Neil VasaniD· 2 shared Abiha KazmiiD· 1 shared Akio YamashitaiD· 1 shared Alexander Kerelsky· 1 shared Alexandre MaucueriD· 1 shared Alexei DegtereviD· 1 shared Alexey G. Ryazanov· 1 shared Amit RegeviD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Neil VasanORCID

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2 papers

Recent·Most cited

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek Simay Gokulu, Sophia Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, Peter V. Hornbeck, Jing Li, Anum Azam Glasgow, Neil Vasan

This paper identifies phosphorylation of SHP2 at tyrosine 62 as a mechanism of resistance to SHP2 inhibitors and a new drug target.

Nature Communications · Mar 3, 2026Peer-reviewedCancer Biology

A global atlas of substrate specificities for the human serine/threonine kinome

Jared Lee Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina M. Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, , Lewis C. Cantley

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

Nature · Jan 11, 2023Peer-reviewedSystems Biology✦ In-depth digest