Author

Wen Yuan

BGI Group (China)Primary ORCID profile (0000-0003-0029-2544 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Wen YuaniD2 papers · Broad Institute

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Xun XuiD· 2 shared Bing HaniD· 1 shared Bolin Yang· 1 shared Bufan Jin· 1 shared Chao LiiD· 1 shared Chen HeiD· 1 shared Chengbin Yan· 1 shared Chengyu LiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Xun XuORCID

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3 papers

Recent·Most cited

Gut Microbiota Dysbiosis-Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage

Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jian‐Dong Huang, Haitao Sun

This study shows that gut microbiota dysbiosis activates the gut NLRP3 inflammasome, worsening CST injury after ICH through a gut-brain axis mechanism.

Interdisciplinary medicine · Sep 22, 2026Peer-reviewedNeuroscience

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

Lei Han, Zhen Liu, Lifang Wang, Yuxuan Liu, Yanrong Wei, Jianyun Ma, Youzhe He, Yichen Zuo, Jiao Fang, Hui Yang, Xiang Zou, Zihan Wu, Min Wang, Wei Liu, Gao Li, , Wei Wu

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

bioRxiv · Oct 13, 2025 · PreprintNeuroscience

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

Qiuju Wang, Jiale Xiang, Junwei Sun, Yun Sik Yang, Jing Guan, Dayong Wang, Cui Song, Ling Guo, Hongyang Wang, Yaqiu Chen, Junhong Leng, Xiaman Wang, Junqing Zhang, Bing Han, Jing Zou, , Zhiyu Peng

This study shows that adding genetic screening to newborn hearing tests in China improves detection and reduces loss-to-follow-up, with significant benefits for identifying preventable hearing loss.

Genetics in Medicine · Mar 19, 2019Peer-reviewedGenetics