Author

Wenbo Wu

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Franziska Michor AiD· 2 shared Chencheng YaoiD· 1 shared Christopher Graser· 1 shared Cole Christini· 1 shared Cristina GuarducciiD· 1 shared Daniel L. AbravaneliD· 1 shared Douglas RussoiD· 1 shared Herbert LevineiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Franziska Michor AORCID

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Author profile →

3 papers

Recent·Most cited

Punctuated mutagenesis promotes multi-stepevolutionary adaptation in human cancers

Christopher Graser, Wenbo Wu, Cole Christini, Mia Petljak, Franziska Michor A

This study shows that punctuated mutagenesis in cancer enhances adaptation by facilitating crossing of fitness valleys through clustered mutations.

eLife · Sep 18, 2026Peer-reviewedCancer Biology

PROFET Predicts Continuous Gene Expression Dynamics from scRNA-seq Data to Elucidate Heterogeneity of Cancer Treatment Responses

Yu-Chen Cheng, Hyemin Gu, Thomas O. McDonald, Wenbo Wu, Shubham Tripathi, Cristina Guarducci, Douglas Russo, Daniel L. Abravanel, Madeline Bailey, Yue Wang, Yun Zhang, Yannis Pantazis, Herbert Levine, Rinath M. Jeselsohn, Markos A. Katsoulakis, Franziska Michor A

Cell Systems · Aug 1, 2026Peer-reviewedBioinformatics

Induction of Sertoli cells from human fibroblasts by NR5A1 and GATA4

Jianlin Liang, Nan Wang, Jing He, Jian Du, Yahui Guo, Lin Li, Wenbo Wu, Longping Liu, Chencheng Yao, Zheng Li, Kehkooi Kee

This study reprograms human fibroblasts into Sertoli cells using NR5A1 and GATA4, showing they resemble primary Sertoli cells and support spermatogonia viability and immune suppression.

bioRxiv · Sep 29, 2018Developmental Biology