Mia Petljak

This study identifies heterogeneous roles of APOBEC3A and APOBEC3B in lung adenocarcinoma mutagenesis using CRISPR-Cas9 and whole-genome sequencing of single-cell clones.

This study shows that punctuated mutagenesis in cancer enhances adaptation by facilitating crossing of fitness valleys through clustered mutations.

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

DupCaller improves mutation detection in duplex sequencing by using sample-specific error profiles and a strand-aware model, increasing sensitivity across various samples and conditions.

This paper describes a method to identify drug resistance mutations in cancer using genome-wide chemical mutagenesis and next-generation sequencing, enabling the discovery of both known and novel resistance mechanisms.