Stability of c-Myc protein differentiates Ras oncogene addiction and MAPK pathway dependency in Ras-mutant multiple myeloma
Ji Luo, Yeon‐Hwa Lee, Christophe Cataisson, Haibo Zhang, Snehal M. Gaikwad, Wendy Dubois, Aleksandra A Michalowski, Howard Hua Yang, Thomas Joshua Meyer, Ryan Young, Beverly A. Mock
This study shows that c-Myc protein stability determines the response of Ras-mutant multiple myeloma cells to RAS and MEK inhibitors, suggesting direct RAS targeting is more effective.
bioRxiv · Aug 7, 2026 · PreprintCancer Biology