DNA binding domain undergoes dynamic and selective protein-protein interactions to facilitate CTCF insulation
Zhou Rong, Kai Tian, Huang Jie, Wenjia Duan, Hongye Fu, Ying Feng, Hui Wang, Yongpeng Jiang, Li Yuanjun, Rui Wang, Jiazhi Hu, Hanhui Ma, Zhi Qi, Xiong Ji
The paper shows that CTCF's DNA binding domain forms dynamic clusters that interact with insulator proteins and avoid transcriptional activators, revealing a mechanism for its insulation function.
bioRxiv · May 15, 2022 · PreprintMolecular Biology