Xiong Ji

This study shows that co-transcriptional RNA processing via the CTD of Pol II is essential for zygotic gene activation, as disrupting it halts mRNA synthesis and increases noncoding RNA levels.

The paper shows that CTCF's DNA binding domain forms dynamic clusters that interact with insulator proteins and avoid transcriptional activators, revealing a mechanism for its insulation function.

This study shows that transcription by Pol I, Pol II, and Pol III has minimal direct effect on 3D chromatin structure in mammalian cells, but indirect effects on chromatin accessibility and Cohesin occupancy are observed.