Jiazhi Hu

Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington's disease deficits in BAC226Q mice

Self-inactivating CRISPR targeting mutant huntingtin in HD mice achieved long-term rescue of neural pathology, motor deficits, weight loss and survival.

Characterizing trajectory-like chromatin architectures with Fun2

The paper introduces Fun2, a reinforcement learning-based algorithm to characterize trajectory-like chromatin architectures, including fountains and stripes, with improved adaptability and accuracy.

Transfer of mitochondrial DNA into the nuclear genome during gene editing

This study shows that genome editing can transfer mitochondrial DNA into the nuclear genome, and provides a solution using TREX1 or TREX2 exonucleases.

DNA binding domain undergoes dynamic and selective protein-protein interactions to facilitate CTCF insulation

The paper shows that CTCF's DNA binding domain forms dynamic clusters that interact with insulator proteins and avoid transcriptional activators, revealing a mechanism for its insulation function.

Cohesin modulates DNA replication to preserve genome integrity

This study shows that cohesin coordinates DNA replication initiation to maintain proper replication timing and genome integrity by affecting dormant origin firing and preventing DNA breaks and translocations.

Global detection of DNA repair outcomes induced by CRISPR-Cas9

The paper develops an in silico pipeline to analyze CRISPR-Cas9-induced DNA repair outcomes, identifying deleterious byproducts like large deletions and chromosomal translocations.