Cytochrome P450 and Epoxide Hydrolase Metabolites in Aβ and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans
Morteza Sarparast, Jennifer Hinman, Elham Pourmand, Derek Vonarx, Leslie Ramirez, Wenjuan Ma, Nicole F. Liachko, Jamie K. Alan, Kin Sing Stephen Lee
This study identifies CYP and EH metabolites involved in Aβ and tau-induced neurodegeneration in C. elegans, showing that EH inhibition reduces neurodegeneration by altering the epoxy-to-hydroxy ratio of CYP-EH metabolites.
bioRxiv · Oct 2, 2023 · PreprintNeuroscience