ImmunologybioRxivPreprint
CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity
Yiru Long, Runqiu Chen, Wenlong Chang…·Likun Gong
This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.
DOI 10.1101/2024.03.05.583639