Fanglin Li

This study identifies the endothelial cell-NK cell-neutrophil axis as a key driver of STING agonist-induced pulmonary inflammation and toxicity.

This study identifies metabolic reprogramming as a mechanism by which CTLA-4 inhibitors cause colitis, showing that metformin can alleviate this toxicity without affecting antitumor efficacy.

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.