SWELL1 channel-mediated D-2HG export promotes immune evasion and metabolic fitness in IDH-mutant gliomas
Yi Cheng, Lifei Ma, Jianan Chen, Jiale Huang, Li Chen, Wenrui Liu, Yongqing Liu, Runxuan Zhao, Yingzhi Ye, Wenqiang Zheng, Lisa Kratz, Maria Graciela Castro, Shuying Sun, Jiangjiang Zhu, Leng Han, Zhaozhu Qiu
This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology