Yi Cheng

This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.

This study identifies KAT7 as an epigenetic regulator that drives microglial mitochondrial immunity and Alzheimer's disease pathogenesis by enhancing mtDNA-driven inflammation and amyloid-β burden.

This study identifies PSA as an inhibitory auxiliary subunit of VRACs, showing its regulatory role is independent of aminopeptidase activity.

This study shows that the proton-activated chloride channel inhibits SARS-CoV-2 entry by blocking endosomal acidification and the cathepsin-dependent pathway.

This study identifies the proton-activated chloride channel as a regulator of phagosome maturation and bacterial killing in peritoneal macrophages, showing its role in immune responses.