Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis
William N. Colgan, Luke W. Koblan, JoAnne Villagrana, Tien-Chi Jason Hou, Minming Wang, Gokul Gowri, Whitney Chandler, Leonardo A. Sepúlveda, Didar Ciftci, Karina Smolyar, Kathryn E. Yost, Alicia Young, Lars Wittler, Styliani Markoulaki, Kyle M. Loh, , Jonathan S. Weissman
Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.
Cell · Oct 1, 2026Peer-reviewedDevelopmental Biology✦ In-depth digest