Chemical perturbations impacting histone acetylation governcolorectal cancer differentiation
Pornlada Likasitwatanakul, Zhixin Li, Khoa Tat Doan, Sándor Spisák, Akhouri Kishore Raghawan, Qi Liu, Priscilla Liow, Sunwoo Liv Lee, David J. Chen, Pratyusha Bala, Pranshu Sahgal, Daulet Aitymbayev, Jennifer S. Thalappillil, Malvina Papanastasiou, William Hawkins, , Nilay S. Sethi
The paper identifies HDAC1/2 inhibition as a method to promote colorectal cancer differentiation through H3K27ac gains, which can be reversed by blocking EP300.
Gastroenterology · Jul 7, 2025Peer-reviewedCancer Biology