Author

Nilay S. Sethi

Broad InstituteORCID 0000-0002-3748-7559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Akhouri Kishore RaghawaniD· 2 shared Zhixin LiiD· 2 shared Agnieszka KraftiD· 1 shared Amanda GarzaiD· 1 shared Andréanne Gagné· 1 shared Andrew J. AguirreiD· 1 shared Breanna M. TitcheniD· 1 shared Camille A. Mathey-AndrewsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Akhouri Kishore RaghawanORCID

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2 papers

Recent·Most cited

Chemical perturbations impacting histone acetylation governcolorectal cancer differentiation

Pornlada Likasitwatanakul, Zhixin Li, Khoa Tat Doan, Sándor Spisák, Akhouri Kishore Raghawan, Qi Liu, Priscilla Liow, Sunwoo Liv Lee, David J. Chen, Pratyusha Bala, Pranshu Sahgal, Daulet Aitymbayev, Jennifer S. Thalappillil, Malvina Papanastasiou, William Hawkins, , Nilay S. Sethi

The paper identifies HDAC1/2 inhibition as a method to promote colorectal cancer differentiation through H3K27ac gains, which can be reversed by blocking EP300.

Gastroenterology · Jul 7, 2025Peer-reviewedCancer Biology

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

Josephine Yates, Camille A. Mathey-Andrews, Jihye Park, Amanda Garza, Andréanne Gagné, Samantha E. Hoffman, Kevin Bi, Breanna M. Titchen, Connor J. Hennessey, Joshua Remland, Matthew L. Carnes, Erin E. Shannon, Sabrina Yvonne Camp, Siddhi Balamurali, Shweta Kiran Cavale, , Eliezer M. Van Allen

The paper analyzes multiomic data from primary and metastatic esophageal adenocarcinoma tumors to identify cell states and their spatial interactions, linking them to clinical outcomes.

Cell Reports Medicine · Jun 1, 2025Peer-reviewedCancer Biology