Author

William Mather

Quantitative BioSciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:statistical model· 1

Frequent Co-Authors

Curtis T. Ogle· 1 shared Joanna T. ZhangiD· 1 shared Nicholas C. ButziniD· 1 shared Oscar S. Velazquez· 1 shared Samuel CastroiD· 1 shared Tal DaninoiD· 1 shared Taylor E. HinchliffeiD· 1 shared Tetsuhiro HarimotoiD· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Curtis T. Ogle

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3 papers

Recent·Most cited

Rapid screening of engineered microbial therapies in a 3-D multicellular model

Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna T. Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, Tal Danino

The paper presents a 3-D multicellular model to rapidly screen engineered microbial therapies, identifying effective antitumor candidates and demonstrating scalability across microbial species.

Proceedings of the National Academy of Sciences · Apr 17, 2019Peer-reviewedSynthetic Biology

Crosstalk Between Diverse Synthetic Protein Degradation Tags In Escherichia coli

Nicholas C. Butzin, William Mather

The paper investigates proteolytic crosstalk between diverse synthetic protein degradation tags in E. coli using microplate reader and single-cell assays, showing crosstalk extends beyond the LAA tag.

ACS Synthetic Biology · Dec 1, 2017Peer-reviewedSynthetic Biology

Proteolytically Coordinated Activation of Toxin-Antitoxin Modules

Curtis T. Ogle, William Mather

The paper presents a theoretical framework explaining how toxin-antitoxin modules interact through proteolytic activity and toxic effects on cell growth to regulate bacterial persistence.

bioRxiv · Jun 4, 2017 · PreprintSystems Biology