Author

Samuel Castro

Columbia UniversityORCID 0000-0003-2598-3210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 1

Frequent Co-Authors

Tal DaninoiD· 3 shared Taylor E. HinchliffeiD· 3 shared Courtney CokeriD· 2 shared Nicholas ArpaiaiD· 2 shared Candice R. GurbatriiD· 1 shared Ioana Lia· 1 shared Joanna T. ZhangiD· 1 shared Oscar S. Velazquez· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersSynthetic Biology

Tal DaninoORCID

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3 papers

Recent·Most cited

Synthetic BiologyScience Translational MedicinePeer-reviewedFeb 12, 2020

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri, Ioana Lia, Rosa L. Vincent…·Tal Danino

The paper designs a probiotic platform to deliver checkpoint blockade nanobodies to tumors using a controlled lysing mechanism for therapeutic release.

648 citationstop 1%

mousestatistical model

𝕏 PostBluesky

Synthetic BiologyNature MedicinePeer-reviewedJul 1, 2019

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury, Samuel Castro, Courtney Coker…·Tal Danino

This paper demonstrates that engineered bacteria can deliver immunotherapeutic payloads to induce durable tumor regression and systemic antitumor immunity.

724 citationstop 1%

mouseexperimental assay

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Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewedApr 17, 2019

Rapid screening of engineered microbial therapies in a 3-D multicellular model

Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez…·Tal Danino

The paper presents a 3-D multicellular model to rapidly screen engineered microbial therapies, identifying effective antitumor candidates and demonstrating scalability across microbial species.

41 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky