A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway
William Paul Steiner, Nathan Iverson, G Liu, Varun Venkatakrishnan, Jian Wu, Tomasz Maciej Stępniewski, Zachary Michaelson, Jan W. Bröckel, Ju‐Fen Zhu, Jessica G. H. Bruystens, Annabel Lee, Isaac B. Nelson, Daniela Bertinetti, Corvin D. Arveseth, Gerald Tan, , Benjamin R. Myers
The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.
Nature Structural & Molecular Biology · Apr 30, 2026Peer-reviewedBiochemistry