Author

Varun Venkatakrishnan

Pennsylvania State UniversityORCID 0000-0002-7169-1684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Ganesh S. AnandiD· 3 shared Amanda J. GrammiD· 1 shared Annabel LeeiD· 1 shared Benjamin R. MyersiD· 1 shared Bindu Y. SrinivasuiD· 1 shared Carla Calvó‐TuselliD· 1 shared Corvin D. ArvesethiD· 1 shared Daniela BertinettiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Ganesh S. AnandORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedAug 5, 2026

Structural Characterization of Native RNA Polymerase II Transcription Complexes and Nucleosomes in Drosophila melanogaster

Natalie L Venette-Smith, Rishi Kishore Vishwakarma, Varun Venkatakrishnan…·Katsuhiko S. Murakami

This study isolates and structures native Pol II transcription complexes and nucleosomes from Drosophila embryos, revealing new insights into transcription dynamics and nucleosome interactions.

DOI 10.1038/s41467-026-75963-0

Drosophilaproteomics

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedApr 30, 2026

A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway

William Paul Steiner, Nathan Iverson, G Liu…·Benjamin R. Myers

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

9 citationstop 1%

proteomicsexperimental assay

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BiophysicsbioRxivPreprintMar 4, 2025

SARS CoV-2 spike adopts distinct conformational ensembles in situ

Amanda J. Gramm, Sean M. Braet, Bindu Y. Srinivasu…·Ganesh S. Anand

This study compares the conformational dynamics of native SARS-CoV-2 Spike protein in virus-like particles to recombinant Spike, finding reduced dynamics in VLP S and implications for epitope display.

DOI 10.1101/2025.03.04.641425

virusstructural biology

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