Pre-division TCF1 drop determines long-term CD8 T cell fates
Natalie R. Favret, Maider Astorkia, Melissa M. Wolf, Michael W. Rudloff, Claudia N. McDavid, Megan M. Erwin, Kristen A. Murray, Jessica J. Roetman, Carlos R. Detrés Román, Zachary D. Ewell, Lincoln A. Brown, William T. Murray, Paul Zumbo, Doron Betel, Mary Philip
This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.
bioRxiv · Oct 6, 2025 · PreprintImmunology