Author

Megan M. Erwin

Vanderbilt UniversityORCID 0000-0002-7014-0856Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Claudia N. McDavid· 3 shared Jessica J. RoetmaniD· 3 shared Kristen A. MurrayiD· 3 shared Lincoln A. BrowniD· 3 shared Mary PhilipiD· 3 shared Melissa M. WolfiD· 3 shared Natalie R. FavretiD· 3 shared Zachary D. EwelliD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Claudia N. McDavid

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TCF1lo CD8 T cells proliferate and persist autonomously in tumors

Megan M. Erwin, Natalie R. Favret, Claudia N. McDavid, Zachary D. Ewell, Melissa M. Wolf, Lincoln A. Brown, Jessica J. Roetman, Michael W. Rudloff, Kristen A. Murray, Carlos R. Detrés Román, Mary Philip

This study shows that TCF1lo CD8 T cells in tumors can proliferate and persist autonomously, challenging the idea that only TCF1hi cells self-renew.

bioRxiv · Jan 21, 2026 · PreprintImmunology

Pre-division TCF1 drop determines long-term CD8 T cell fates

Natalie R. Favret, Maider Astorkia, Melissa M. Wolf, Michael W. Rudloff, Claudia N. McDavid, Megan M. Erwin, Kristen A. Murray, Jessica J. Roetman, Carlos R. Detrés Román, Zachary D. Ewell, Lincoln A. Brown, William T. Murray, Paul Zumbo, Doron Betel, Mary Philip

This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.

bioRxiv · Oct 6, 2025 · PreprintImmunology

MDR1 promotes CD8 T cell persistence in tumors and protects against cytotoxic chemotherapy

Lincoln A. Brown, Megan M. Erwin, Natalie R. Favret, Claudia N. McDavid, Jessica J. Roetman, Zachary D. Ewell, Melissa M. Wolf, Kristen A. Murray, Jack E. Smithwick, Marti Goemann, Mary Philip

This study shows that MDR1 promotes CD8 T cell persistence in tumors and protects against chemotherapy-induced cell death.

bioRxiv · Sep 28, 2025 · PreprintImmunology