Paul Zumbo

This study identifies Scleraxis a as a key regulator of epicardial progenitor differentiation into a unique cardiac perivascular cell type in zebrafish, revealing a hypoxia-responsive pathway involved in coronary vessel development.

This study investigates how different KRAS mutations drive distinct phenotypic outcomes in pancreatic tumorigenesis, revealing mutation-specific oncogenic pathways and therapeutic implications.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study identifies CEBPD as a tumor suppressor gene in acute myeloid leukemia through functional experiments and genomic analyses.

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.

This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.

The paper identifies an IFN-STAT1-CYBB axis that mediates protective crosstalk between plasmacytoid dendritic cells and neutrophils during Aspergillus fumigatus infection.

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

The paper identifies a transient epicardial progenitor cell population in zebrafish that is essential for heart regeneration through single-cell RNA sequencing and functional analysis.

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.