Carlos R. Detrés Román

This study shows that TCF1lo CD8 T cells in tumors can proliferate and persist autonomously, challenging the idea that only TCF1hi cells self-renew.

This study shows that TCF1 expression drops before CD8 T cells divide, and this drop predicts their long-term fate as effectors or memory cells.

This study shows vaccination generates functional progenitor tumor-specific CD8 T cells and halts liver cancer progression in a mouse model, while immune checkpoint blockade does not.