TCF1lo CD8 T cells proliferate and persist autonomously in tumors
Megan M. Erwin, Natalie R. Favret, Claudia N. McDavid, Zachary D. Ewell, Melissa M. Wolf, Lincoln A. Brown, Jessica J. Roetman, Michael W. Rudloff, Kristen A. Murray, Carlos R. Detrés Román, Mary Philip
This study shows that TCF1lo CD8 T cells in tumors can proliferate and persist autonomously, challenging the idea that only TCF1hi cells self-renew.
bioRxiv · Jan 21, 2026 · PreprintImmunology