Chemotherapy accelerated bone ageing is reversed by NMN
Maria B. Marinova, Romanthi J. Madawala, Wing-Hong Jonathan Ho, Vedran Lovric, Michael J. Bertoldo, Rema A. Oliver, Jayanthi Maniam, Margaret J. Morris, David A. Sinclair, Hayden Anthony Homer, Kirsty A. Walters, Jonathan Erlich, William Robert Walsh, Robert Bruce Gilchrist, Lindsay E. Wu
This study shows that chemotherapy-induced bone ageing in mice is reversed by NMN treatment, through mechanisms involving phosphorus homeostasis and renal protection.
bioRxiv · Oct 13, 2025 · PreprintPhysiology