Robert Bruce Gilchrist

This study identifies proteomic differences between in vivo and in vitro matured mouse oocytes, revealing dysregulated pathways in in vitro systems and conserved patterns in human oocytes.

This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.

This study shows that chemotherapy-induced bone ageing in mice is reversed by NMN treatment, through mechanisms involving phosphorus homeostasis and renal protection.

This study shows how oocyte-secreted factors alter proteomic and metabolic profiles of oocytes and cumulus cells during maturation, enhancing their cooperativity for fertilization.

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.