This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.

bioRxiv · Jul 23, 2026 · PreprintCell Biology

Chemotherapy accelerated bone ageing is reversed by NMN

Maria B. Marinova, Romanthi J. Madawala, Wing-Hong Jonathan Ho, Vedran Lovric, Michael J. Bertoldo, Rema A. Oliver, Jayanthi Maniam, Margaret J. Morris, David A. Sinclair, Hayden Anthony Homer, Kirsty A. Walters, Jonathan Erlich, William Robert Walsh, Robert Bruce Gilchrist, Lindsay E. Wu

This study shows that chemotherapy-induced bone ageing in mice is reversed by NMN treatment, through mechanisms involving phosphorus homeostasis and renal protection.

bioRxiv · Oct 13, 2025 · PreprintPhysiology

NAD+ repletion rescues female fertility during reproductive ageing

Michael J. Bertoldo, Dave R. Listijono, Wing-Hong Jonathan Ho, Angelique H. Riepsamen, Xing Liang Jin, Kaisa L. Selesniemi, Dale Mark Goss, Saabah B. Mahbub, Jared M. Campbell, Abbas Habibalahi, Wei‐Guo Nicholas Loh, Neil A. Youngson, Jayanthi Maniam, Ashley S.A. Wong, Dulama Richani, , Lindsay E. Wu

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.

bioRxiv · Aug 2, 2019 · PreprintDevelopmental Biology