Lindsay E. Wu

A proteomic signature of oocyte quality from models of varying oocyte developmental competence

This study identifies proteomic differences between in vivo and in vitro matured mouse oocytes, revealing dysregulated pathways in in vitro systems and conserved patterns in human oocytes.

Aging disrupts cumulus-oocyte NAD homeostasis

This study identifies age-related disruption in cumulus-oocyte NAD homeostasis through metabolic coupling, showing that NMN supplementation improves oocyte redox status in aged mice.

Chemotherapy accelerated bone ageing is reversed by NMN

This study shows that chemotherapy-induced bone ageing in mice is reversed by NMN treatment, through mechanisms involving phosphorus homeostasis and renal protection.

CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN)

The paper shows CD38 mediates base exchange on NMN to produce NaMN, linking salvage and de novo NAD+ pathways.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

NAD+ repletion rescues female fertility during reproductive ageing

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.