ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding
Q. Chen, C. T. Schafer, S. Mukherjee, M. Gustavsson, P. Agrawal, X.-Q. Yao, A. A. Kossiakoff, T. Handel, J. J. G. Tesmer
This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.
bioRxiv · Jul 18, 2023 · PreprintBiochemistry