Author

C. T. Schafer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J. J. G. Tesmer· 2 shared M. Gustavsson· 2 shared Q. Chen· 2 shared T. M. Handel· 2 shared A. A. Kossiakoff· 1 shared D. P. Millar· 1 shared P. Agrawal· 1 shared R. F. Pauszek· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

J. J. G. Tesmer

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Author profile →

3 papers

Recent·Most cited

Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes

C. T. Schafer, R. F. Pauszek, M. Gustavsson, T. M. Handel, D. P. Millar

This study uses single-molecule FRET to compare conformational dynamics of CXCR4 and ACKR3, revealing distinct activation mechanisms and conformational landscapes.

bioRxiv · Oct 31, 2023Biophysics

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

Q. Chen, C. T. Schafer, S. Mukherjee, M. Gustavsson, P. Agrawal, X.-Q. Yao, A. A. Kossiakoff, T. Handel, J. J. G. Tesmer

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.

bioRxiv · Jul 18, 2023 · PreprintBiochemistry

Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

C. T. Schafer, Q. Chen, J. J. G. Tesmer, T. M. Handel

This study shows that ACKR3 senses CXCR4 activation via GRK2-dependent phosphorylation, with GRK5 playing a dominant role in {beta}-arrestin recruitment and chemokine scavenging.

bioRxiv · Feb 25, 2023Biochemistry