P. Agrawal

Clinical, in vitro, and in vivo evidence of WAPL as a novel cohesinopathy gene and phenotypic driver of 10q22.3q23.2 genomic disorder

The paper identifies WAPL as a novel cohesinopathy gene and driver of a genomic disorder, showing its role in developmental delay and other anomalies through clinical, in vitro, and in vivo analyses.

Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance

SonoPrint: Acoustically Assisted Volumetric 3D Printing for Composites

SonoPrint uses acoustics to pattern microparticles in 3D-printed composites, enhancing mechanical strength by 38% in tension and 75% in compression.

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.

DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

DIETS measures and controls solid food intake in Drosophila without labels, showing high-fat diets don't improve starvation resistance despite higher calorie consumption.

Adjuvants influence the maturation of VRC01-like antibodies during immunization

The study examines how three adjuvants affect the mutation patterns and antibody titers of VRC01-class BCRs during immunization with specific immunogens.

Broad misappropriation of developmental splicing profile by cancer in multiple organs

The paper shows cancer reactivates embryonic splicing events, linking development and cancer through splicing factors and identifies potential therapeutic targets.

Microfluidic Device Facilitates Novel In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip

The paper introduces a microfluidic model of human neonatal small intestinal epithelium to study NEC, showing inflammation, barrier disruption, and epithelial dysfunction.

A metastable contact and structural disorder in the estrogen receptor transactivation domain

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

Safety evaluation of soy leghemoglobin protein preparation derived from Pichia pastoris, intended for use as a flavor catalyst in plant-based meat

This study evaluates the safety of soy leghemoglobin protein derived from Pichia pastoris for use in plant-based meat, finding it non-mutagenic and non-toxic at high doses.