Mechanical stretch disrupts calcium dynamics and redistributes Piezo1 in human astrocytes
Shahrzad Shiravi, Akash Chakka, Xi Xiao, Meilín Fernández García, Alexandra Yufa, Angela Mitevska, Carina Seah, H Gao, Laura M. Huckins, Kristen Brennand, John D. Finan
This study uses a 2D stretch injury model to show that mechanical stretch disrupts calcium dynamics, mitochondrial function, and Piezo1 distribution in human astrocytes, with temporary effects at moderate injury severity.
Annals of Biomedical Engineering · Feb 5, 2026Peer-reviewedNeuroscience