YAP1 Depletion Enhances TAZ and its Complexation with TEAD4 and AP-1 Heterodimer C-JUN/FOSB to Promote Gastric Cancer Progression and Metastases
Jingjing Wu, Dipti Athavale, Curt Balch, Junsong Zhao, Gengyi Zou, Yibo Fan, Yan-ting Yann Zhang, Joseph Jonathan Zhao, Mikel D. Ghelfi, Anthony Pompetti, Gennaro Calendo, Ailing W. Scott, Shan Shao, Xiao-Dan Yao, Melissa Pool Pizzi, , Shumei Song
This study shows that inhibiting both YAP1 and TAZ in gastric cancer peritoneal metastases reduces tumor growth and progression by blocking their interactions with TEAD4 and AP-1 complexes.
bioRxiv · Nov 13, 2025 · PreprintCancer Biology