TIM3+ Tumor Associated M2 Macrophages Impair Antitumor T Cell Immunity and Promote Gastric Cancer Progression and Peritoneal Metastasis
Xiaodan Yao, Yibo Fan, Junsong Zhao, Yan-ting Yann Zhang, Dipti Athavale, Curt Balch, Mikel D. Ghelfi, Anthony Pompetti, Joseph Zhao, Ailing W. Scott, Jiankang Jin, Young Ki Hong, Jamin Morrison, Madeline Torres, Shilpa S. Dhar, , Shumei Song
This study shows TIM3 on M2 macrophages promotes gastric cancer progression and metastasis by suppressing T cell immunity, and TIM3 blockade combined with immunotherapy and chemotherapy improves outcomes.
bioRxiv · Apr 17, 2026 · PreprintImmunology