Effective methods for bulk RNA-Seq deconvolution using scnRNA-Seq transcriptomes
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica L. Epps, Xiaochen Long, Tsz‐Kwong Man, Hua‐Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael Krueger, Diego di Bernardo, Luis Filipe Voloch, Jan J. Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, , Pavel Sumazin
The paper evaluates deconvolution methods for bulk RNA-Seq using scnRNA-Seq data, identifies biases, and introduces SQUID, a method that outperforms others in predicting cell mixtures and identifying cancer subclones.
Genome biology · Aug 1, 2023Peer-reviewedSystems Biology