A minor muscle stem cell population functions as metabolic Trojan horse fueling systemic aging by succinate induced epigenetic reprogramming
Xiaofen Wu, Meng Chen, Ruqi Fan, Hongye Wang, Ruimiao Ma, Xiaocui Tang, Hui Wang, Wei Wei, Jiemin Wong, Guoliang Xu, Ping Hu
This study identifies muscle stem cells as drivers of systemic inflammaging through succinate-induced epigenetic reprogramming, linking metabolic dysregulation to aging phenotypes.
bioRxiv · Dec 26, 2025 · PreprintCell Biology