Jing Pu

InsilicoCell predicts cellular functional profiles and enables multi-objective virtual drug screening by integrating diverse molecular data and tasks.

GEOMeta automates metadata curation for GEO transcriptomic data, generating standardized annotations for 600,000 human bulk RNA-seq samples and benchmarking LLMs for annotation quality.

This study shows SARS-CoV-2 ORF3a disrupts lysosomal cholesterol export by interfering with VPS39-regulated NPC2 trafficking and BMP metabolism.

This study identifies HSD17B11 as a regulator that maintains FSP1 localization on lipid droplets, supporting ferroptosis defense.

This study examines metabolomic, lipidomic, and enterohormone changes during progression from MASLD to MASH in mice, identifying cholic acid elevation and altered enteroendocrine hormone levels.

This study identifies processing bodies (PBs) as critical for lysosomal quality control and cell survival during recovery from lysosomal damage, distinguishing their role from the acute damage response.

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

This study identifies amino acids that regulate lysosome positioning and shows that combining lysosome-dispersing amino acids with mTOR-activating ones synergistically enhances mTOR activation, particularly in cancer cells.