Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit
Xuan Ling Hilary Yong, Lingrui Zhang, Liming Yang, Xiumin Chen, Jing Zhi Anson Tan, Xiaojun Yu, Mintu Chandra, Emma K. Livingstone, Jocelyn Widagdo, Marta Mota Vieira, Katherine W. Roche, Joseph W. Lynch, Angelo Keramidas, Brett M. Collins, Victor Anggono
This study identifies CaMKIIα-mediated phosphorylation of GluN2A at Ser-1459 as a mechanism regulating NMDAR trafficking and gating, with implications for epilepsy.
Cell Reports · Jul 1, 2021Peer-reviewedNeuroscience