Twin study provides heritability estimates for 2,321 plasma proteins and assesses missing SNP heritability
Gabin Drouard, Fiona A. Hagenbeek, Miina Ollikainen, Zhili Zheng, Xiaoling Wang, FinnGen, Samuli Ripatti, Matti Pirinen, Jaakko A. Kaprio
The paper estimates heritability for 2,321 plasma proteins using twin data and finds that SNP-based heritability accounts for only half of the total genetic effects.
Journal of Proteome Research · May 27, 2025Peer-reviewedGenetic & Genomic Medicine