Fiona A. Hagenbeek

The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases

This study examines how polygenic scores and socioeconomic status jointly influence risk for 19 diseases, finding distinct and partly interacting effects across populations.

Twin study provides heritability estimates for 2,321 plasma proteins and assesses missing SNP heritability

The paper estimates heritability for 2,321 plasma proteins using twin data and finds that SNP-based heritability accounts for only half of the total genetic effects.

Intergenerational transmission of complex traits and the offspring methylome

The paper investigates how parental polygenic scores for complex traits are associated with offspring DNA methylation, finding significant links for schizophrenia, educational attainment, BMI, and height.

Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder

This study integrates genomics, epigenomics, and metabolomics data to identify ADHD biomarkers and explore omics-level connections, finding associations between PGSs, CpGs, and metabolites.

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

This study identifies proteins and genes associated with BMI and its changes in twins, showing shared genetic and environmental factors across proteome, transcriptome, and metabolome layers.

A Multi-omics Data Analysis Workflow Packaged as a FAIR Digital Object

The paper develops a multi-omics data analysis workflow packaged as a FAIR Digital Object to improve reproducibility and reuse in computational research.

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

This study examines heritability of urinary metabolites in children, finding substantial genetic contributions across amines, organic acids, and steroids.

Genetic Association Study of Childhood Aggression across raters, instruments and age

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The genomic architecture of blood metabolites based on a decade of genome-wide analyses

This study estimates heritability and genetic contributions to metabolite levels using genome-wide data and twin-family cohorts, revealing class-specific genetic influences.